Dr. Holmes

Dennis R. Holmes, MD

Dennis R. Holmes, MD, is an internationally renowned breast surgeon specializing in the surgical treatment of breast cancer and non-cancerous breast conditions. He completed his medical education at Tulane University School of Medicine, surgical residency in general surgery at the University of San Francisco, and a fellowship in breast surgery at the University of Southern California.

As a dedicated breast surgeon, Dr. Holmes has dedicated his career to breast cancer treatment innovation to reduce the burden of breast cancer care. He was a pioneering investigator in the TARGIT-A clinical trial that established the effectiveness of single-dose targeted intraoperative partial breast radiotherapy as an alternative to conventional six-week daily whole breast radiotherapy. He currently serves as coprincipal investigator of the TARGIT-US Registry Trial and as president of the TARGIT Collaborative Group, a national organization of surgeons, radiation oncologists, and physicists committed to improving cancer patient care through education, patient advocacy, mentorship, and collaborative research. Dr. Holmes also serves as national principal investigator of the FROST trial, a multicenter trial evaluating the role of cryoablation or tumor freezing in the management of early-stage breast cancer.

Dr. Holmes is a board certified fellow of the American College of Surgeons and recently held the position of program chair of the 20th Annual National Meeting of the American Society of Breast Surgeons. As a sought-after physician educator, Dr. Holmes is also a frequent lecturer at medical conferences around the globe. Most important to his patients, Dr. Holmes is a warm, caring breast surgeon who possesses the expertise, empathy, and patience to help each patient find a breast cancer solution that suits them physically and emotionally while providing the best possible cancer control.